Thus, immune components have been targeted to promote chronic wound repair or skin regeneration and several growth factors, cytokines, and biomaterials have shown promising results in animal models. Recent Advances: Recent studies have revealed the key roles of various immune cells and immune mediators in skin repair.
This review discusses the pathophysiology of both acute and chronic wounds and possible strategies to control the immune system to accelerate chronic wound closure and promote skin regeneration (scar-less healing) of acute wounds.
Hence, controlling the immune system to promote tissue repair and regeneration is an attractive approach when designing regenerative strategies.
Significance: The immune system plays a central role in orchestrating the tissue healing process.
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